The role of SGOL1 in the prognosis of skin cutaneous melanoma (SKCM)
SGOL1在皮肤黑色素瘤（SKCM）预后中的作用：目的：分析皮肤黑色素瘤（SKCM）中SGOL1的表达及其与预后的关系。方法：利用TCGA数据库分析SGOL1在SKCM及正常组织中的表达。采用Kaplan-Meier曲线分析SGOL1表达与SKCM预后的关系。 Mann-Whitney U检验和Kruskal-Wallis检验用于分析SGOL1与临床病理特征的关系。结果：SGOL1在SKCM中过度表达（P<0.05）。 SGOL1高表达组的总生存期低于低表达组（P < 0.05）。 SGOL1的表达在性别和年龄组之间没有差异，但SGOL1的表达在Clark分级、肿瘤分期和生存状态之间存在差异。结论：SKCM中SGOL1高表达可能与预后不良有关。
Keywords:Skin Cutaneous Melanoma, SGOL1, TCGA
Objective: To analyze the expression of SGOL1 in skin cutaneous melanoma(SKCM) and its relationship with prognosis. Methods: The expression of SGOL1 in SKCM and normal tissues was analyzed by TCGA database. Kaplan-Meier curve was used to analyze the relationship between SGOL1 expression and prognosis of SKCM. Mann-Whitney U test and Kruskal-Wallis test were used to analyze the relationship between SGOL1 and clinicopathological features. Results:SGOL1 was over expressed in SKCM (P <0.05). The overall survival of SGOL1 high expression group was lower than low expression group (P < 0.05). There was no difference in the expression of SGOL1 between gender or age groups, but there were different in the expression of SGOL1 between Clark grades, tumor stages and survival status. Conclusion: High expression of SGOL1 in SKCM may be related with poor prognosis.
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